Promethazine HCl and Codeine Phosphate Oral Remedy needs to be made use of with caution in patients with extreme impairment of renal operate, and patients ought to be monitored intently for respiratory despair, sedation, and hypotension.
Antihistamines and codeine are both contraindicated for use during the therapy of lessen respiratory tract symptoms, like bronchial asthma.
Limited knowledge suggest that usage of promethazine hydrochloride throughout labor and shipping does not have an considerable impact on the length of labor or supply and isn't going to improve the risk of have to have for intervention while in the new child.
Acute or significant bronchial asthma in an unmonitored location or in absence of resuscitative tools. (four)
Promethazine hydrochloride and codeine phosphate ought to be presented to some pregnant lady provided that Evidently essential.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers less than 6 years of age. Concomitant administration of promethazine solutions with other respiratory depressants has an Affiliation with respiratory depression, and sometimes death, in pediatric patients. The Affiliation does circuitously relate to individualized bodyweight-based mostly dosing, which could otherwise allow Harmless administration.
Discontinuation of the concomitantly applied cytochrome P450 2D6 inhibitor might result in a lessen in codeine plasma concentration and a rise in Lively metabolite morphine plasma focus which could boost or extend adverse reactions and will lead to probably deadly respiratory depression.
Suggest individuals to normally use an exact milliliter measuring system when measuring and administering Promethazine HCl and Codeine Phosphate Oral Option. Tell individuals that a house teaspoon isn't an exact measuring product and these use may lead to overdosage and critical adverse reactions [see Overdosage (10)].
Labor or Supply Opioids cross the placenta and may develop respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, like naloxone, must be accessible for reversal of opioid-induced respiratory despair inside the neonate.
Correct assessment with the affected person, correct prescribing procedures, periodic re-evaluation of therapy, and appropriate dispensing and storage are acceptable steps that assist to limit abuse of opioid medicines.
Will Promethazine codeine syrup not choose any benzodiazepines or medicines that can result in drowsiness or sleepiness all through treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Solution. Question your Health care company for an index of these medicines if You aren't sure.
This medicine is taken only when desired, so there won't be any Distinctive instructions for any missed dose. Dosing The dose of this medicine will probably be various for different individuals. Observe your health practitioner's orders or perhaps the directions around the label. The following information includes only the normal doses of the medicine. When your dose is different, don't modify it Until your health practitioner lets you know to do so.
Codeine might cause really serious unwanted outcomes if taken by Grown ups, youngsters, or pets that are not utilized to strong narcotic suffering medicines. Be sure to shop the medication in a safe and secure put to circumvent others from receiving it. Fall off any unused narcotic medication in a drug get-back again site straight away.
Drug interactions might adjust how your remedies get the job done or increase your threat for really serious Unwanted effects. This doc does not have all achievable drug interactions.